Live out your rock star dreams of music, luxury, and five-star treatment at the Hard Rock Hotel & Casino Biloxi. Escape to Margaritaville Resort Biloxi, now open overlooking Deer Island and the Mississippi Sound! Our 22 story family-friendly resort with spacious rooms. Biloxi Hotels | BEST WESTERN Oak Manor| Biloxi Casino Hotels . Biloxi, Mississippi United States. CHECK-IN. P.M. CST. Toll Free Reservations.